Abstract: To address challenges in compressed air systems for power semiconductor manufacturing plants—including significant pressure fluctuations, prolonged idle periods, insufficient post-processing coordination, and coarse energy management—we propose a PLC-centric centralized control system for air compressor clusters. The system establishes an integrated architecture encompassing sensor acquisition, actuator coordination, human-machine interaction, communication diagnostics, and alarm protection mechanisms, structured around the "main unit, gas storage, drying, gas distribution, and load" operational chain. Key energy-saving strategies include variable load regulation based on pressure ranges, balanced runtime scheduling, time-of-use gas storage with peak-valley electricity pricing, and idle suppression mechanisms. Case study from an air compressor station retrofit in a power semiconductor manufacturing workshop demonstrated that the system successfully maintained total pipeline pressure fluctuations within ±0.013 MPa, reduced idle ratios by 11 percentage points, and decreased unit gas supply power consumption by 9.6%. These findings provide practical references for centralized control systems in power semiconductor manufacturing plant air compressor clusters.