Abstract: High-voltage electrical equipment is the core of power engineering, and its seismic performance is directly related to the stability of power supply during earthquakes, which affects social and economic order and public safety. This study takes the Xiaze 500 kV Substation in Fujian, located in a seismic intensity zone of 8 degrees (with a fortification intensity of 9 degrees), as the research object. Combining the structural characteristics and seismic requirements of equipment such as transformers and reactors, a differentiated seismic isolation and vibration reduction scheme is proposed: the integral seismic isolation technology is adopted for transformers, and the energy-dissipating vibration reduction technology at the top of supports is applied to open-type support equipment. Through scheme design, parameter calculation, on-site implementation, and analysis of technical and economic benefits, the comprehensive advantages of this system in improving seismic capacity, reducing costs, and ensuring rapid post-disaster recovery are verified. The results show that the vibration reduction rates of equipment acceleration, displacement, and root stress are all ≥30%, which can effectively avoid the risk of seismic damage. This achievement provides technical support for the safe construction of the Xiaze Substation and also offers a promotable scheme for the seismic design of similar substations in high-intensity seismic zones.