Abstract: With the increasing penetration rate of electric vehicles (EVs) and distributed generators (DGs) in active distribution networks, active distribution networks are facing the dual challenges of increasing source-load power mismatch and deteriorating voltage stability. The intelligent soft open point (SOP) has the ability to continuously adjust the power transmission, which provides a new technical approach for the precise voltage regulation of the distribution network. In this paper, an active distribution network operation optimization strategy with SOP is proposed. Firstly, the Monte Carlo simulation method is used to construct the day-ahead scene set, so as to describe the uncertainty characteristics of the power on both sides of the source and load; then, the cooperative operation architecture between SOP and traditional reactive voltage regulation equipment was constructed, and an optimization model was constructed with the goal of minimizing network loss and voltage deviation. Finally, the simulation results show that the proposed method has significant effect in improving the system economy and voltage quality.