Abstract: Aiming at the low anti-misoperation safety performance and relatively low operational efficiency of the centralized control system during control operations, a centralized control system programmatic control technology based on the dual anti-misoperation verification is proposed. The anti-misoperation master station is added to the centralized control station to interact with the centralized control system and substation anti-misoperation hosts in order to achieve the unique operational authority management and the master-slave station synchronous anti-misoperation logic. When the centralized control system performs programmatic control operations, it requests unique operational authority from the anti-misoperation master station to undergo dual anti-misoperation verification. The engineering application results show that the safety performance and operational efficiency of the centralized control system control operation have been improved through the use of programmatic control technology.