Abstract: In order to reduce the network loss in the operation of distribution network, taking the new energy distribution network as an example, this paper puts forward a coordinated optimization method based on the improved grey wolf algorithm. Taking the minimum network loss and minimum voltage deviation as the main objectives, the fitness function of the objective function is established; based on power balance, node voltage limit, branch current capacity and other constraints, the fitness of the objective function is constrained and optimized. By introducing chaos mapping and adaptive weight to optimize the grey wolf algorithm, and using the improved algorithm to solve the objective function, the coordinated optimization of distribution network operation is realized. The experimental results show that this method can reduce the network loss of new energy distribution network and improve its convergence performance.