Abstract: In order to enhance the collaborative operation efficiency of the high-voltage power supply system and the distributed control system (DCS) of the electrostatic precipitator in power plants, this study takes the 2×600 MW units of a certain coal-fired power plant as a case, focuses on the control architecture design of the deep integration of the high-voltage power supply system and DCS, systematically analyzes the deficiencies of the traditional system in the adaptability to working conditions and fault response, and constructs a three-layer collaborative control architecture. And a control strategy based on adaptive regulation of working conditions, fault-tolerant processing and energy-saving optimization was proposed. The research results show that through real-time data interaction and intelligent control mechanisms, this architecture effectively enhances the system's adaptability to complex working conditions, significantly improving operational stability and economy.