Abstract: With the advancement of China's energy strategy to the high-altitude areas in the west, the construction demand for power transmission and transformation projects in high-altitude and complex environments is increasing. However, special conditions such as low oxygen, low temperature, strong ultraviolet radiation and complex terrain in high-altitude areas significantly increase the project risk. In this paper, a 110 kV power transmission and transformation project in a high-altitude area is taken as the research object, combined with the analytic hierarchy process (AHP) and the fuzzy comprehensive evaluation method (FCE), the key risk factors such as environment, technology, and safety in the project are systematically identified and evaluated, and the evaluation model of power system safety production management is constructed. By constructing a multi-level risk evaluation index system, the weights of each risk are calculated and the overall risk level evaluation is determined. The results of this paper can provide scientific reference and reference for the risk management of similar high-altitude power transmission and transformation projects.