Abstract: In the optimization control of power generation units, local optimization is often carried out for a single unit under specific conditions without considering the coupling characteristics of equipment operation among multiple units under full load conditions and the load distribution across units. This leads to an increased risk of equipment failure and a higher coal consumption rate. Based on the above background, a coordinated optimization control method for multiple 1000 MW units under full load conditions is studied. This method first monitors the operating status of key equipment of the units and performs optimization control through manual intervention strategies. Furthermore, a coal consumption model is established to achieve load distribution across units. Finally, feedforward-feedback control and fuzzy PID control are applied to the key parameters of multiple units, and coordinated optimization control is completed in conjunction with a multi-parameter coupling model. Case analysis results show that this method can enhance the safety and economy of multiple units under full load conditions.