Abstract: At present, the social demand for power supply is increasing. How to effectively meet the power demand and improve the stability and reliability of the power grid has become an urgent problem to be solved. Through the new 110 kV substation project technology research and design implementation, the introduction of advanced load forecasting technology and tide calculation model, considering the braking characteristics of transformer differential protection value calculation and calibration, ensure the stability of the power grid at the same time, the analysis how to effectively manage and use renewable energy, to meet the current power demand and for the future of the power grid upgrade and intelligent lay a solid foundation.