Abstract: This paper systematically discusses the application of intelligent sensing technology in urban and rural power grid real-time monitoring, and analyzes the architecture design of real-time monitoring system and the selection of intelligent sensors in detail, including the selection and application of voltage sensors, current sensors, temperature sensors and vibration sensors. This paper verifies the effectiveness of intelligent sensing technology through experimental cases. The experimental results show that the monitoring system based on intelligent sensing technology is obviously superior to the traditional monitoring system in terms of fault detection and response time.